Broadcaster Alan Jones will have his last day on air on Wednesday ahead of prostate cancer surgery.

The 67-year-old is scheduled to have an operation to remove the cancer at Sydney's St Vincent's Hospital on Saturday.

He will spend Thursday and Friday resting.

A spokeswoman for Jones said the breakfast host was in good spirits.

"He's feeling fine, he's very positive," the spokeswoman said.

Jones, who has vowed not to give up on his radio career, is expected to be off air for two to three weeks while he recuperates.

"He'll probably be off for a few weeks but it's up in the air because it's one of those things you don't know how you're going to feel after a major operation," the spokeswoman said.

He will be replaced by Jason Morrison.

The influential radio host and former Wallabies rugby coach found out about his illness after a biopsy in May, but did not tell friends, family and colleagues until earlier this month because he did not want to cause concern.